Copyright © 2020, Radcliffe Cardiology.Heart failure (HF), with steadily increasing incidence rates and mortality in an ageing population, represents a major challenge. Evidence suggests that more than half of all patients with a diagnosis of HF suffer from HF with preserved ejection fraction (HFpEF). Emerging novel biomarkers to improve and potentially guide the treatment of HFpEF are the subject of discussion. One of these biomarkers is suppression of tumourigenicity 2 (ST2), a member of the interleukin (IL)-1 receptor family, binding to IL-33. Its two main isoforms - soluble ST2 (sST2) and transmembrane ST2 (ST2L) - show opposite effects in cardiovascular diseases. While the ST2L/IL-33 interaction is considered as being cardioprotective, sST2 antagonises this beneficial effect by competing for binding to IL-33. Recent studies show that elevated levels of sST2 are associated with increased mortality in HF with reduced ejection fraction. Nevertheless, the significance of sST2 in HFpEF remains uncertain. This article aims to give an overview of the current evidence on sST2 in HFpEF with an emphasis on prognostic value, clinical association and interaction with HF treatment. The authors conclude that sST2 is a promising biomarker in HFpEF. However, further research is needed to fully understand underlying mechanisms and ultimately assess its full value. Copyright © 2020, Radcliffe Cardiology.Background Motion sensitivity, or motion sickness, is common in modern vehicular and visually stimulating environments. Several studies have shown a relationship between motion sensitivity and decreased postural stability. We aimed to evaluate the effects of head motion (horizontal and vertical) on postural stability in healthy adults with and without chronic motion sensitivity (CMS). Methods Sixty healthy adult men and women (age, 20-40?years) with CMS (CMS group, n?=?30) and without CMS (non-CMS group, n?=?30) participated in the study. Postural stability was assessed during three conditions (static, horizontal head motion, and vertical head motion) using computerized dynamic posturography. Group and condition-related differences in equilibrium scores were evaluated. Results There was no significant group x condition interaction (F2,114?=?0.9, partial ?2?=?0.04, p?=?0.35). However, significant condition-related differences in equilibrium scores were observed (F2,114?=?26.4, partial ?2?=?0.31, p? less then ?0.001). Equilibrium scores were significantly worse in the horizontal and vertical head motion conditions compared to those in the static condition (p? less then ?0.001), but were comparable in vertical and horizontal head motion conditions (p?=?0.27). Conclusions Postural stability was lower in the horizontal and vertical conditions compared to the static condition. However, horizontal and vertical head motions had comparable effects on postural stability in both CMS and non-CMS groups, contrary to our expectations. © The Author(s) 2020.Structural variations (SVs) influence the development and progression of multiple types of cancer. The genes affected by SVs in hepatocellular carcinoma (HCC) and their contribution to tumor growth and metastasis remain unknown. In this study, through whole-genome sequencing (WGS), we identified MACROD2 as the gene most frequently affected by SVs, which were associated with low MACROD2 expression levels. Low MACROD2 expression was predictive of tumor recurrence and poor overall survival. MACROD2 expression was decreased in HCC cell lines, especially those with high metastatic potential. MACROD2 knockdown in HCC cells markedly enhanced proliferation and invasiveness in vitro and tumor progression in vivo and promoted epithelial-mesenchymal transition (EMT). By contrast, MACROD2 overexpression reversed EMT and inhibited HCC growth and metastasis. Mechanistically, MACROD2 deficiency suppressed glycogen synthase kinase-3β (GSK-3β) activity and activated β-catenin signaling, which mediated the effect of MACROD2 on HCC. In clinical HCC samples, decreased MACROD2 expression was correlated with the activation of GSK-3β/β-catenin signaling and the EMT phenotype. Overall, our results revealed that MACROD2 is frequently affected by SVs in HCC, and its deficiency promotes tumor growth and metastasis by activating GSK-3β/β-catenin signaling. © The Author(s) 2020.[This corrects the article DOI 10.1038/s41540-019-0112-5.]. © The Author(s) 2020.While the outstanding properties of graphene have attracted a lot of attention, one of the major bottlenecks of its widespread usage is its availability in large volumes. Laser printing graphene on polyimide films is an efficient single-step fabrication process that can remedy this issue. A laser-printed, flexible pressure sensor is developed utilizing the piezoresistive effect of 3D porous graphene. The pressure sensors performance can be easily adjusted via the geometrical parameters. They have a sensitivity in the range of 1.23 × 10-3 kPa and feature a high resolution with a detection limit of 10 Pa in combination with an extremely wide dynamic range of at least 20 MPa. They also provide excellent long-term stability of at least 15 000 cycles. https://www.selleckchem.com/products/sabutoclax.html The biocompatibility of laser-induced graphene is also evaluated by cytotoxicity assays and fluorescent staining, which show an insignificant drop in viability. Polymethyl methacrylate coating is particularly useful for underwater applications, protecting the sensors from biofouling and shunt currents, and enable operation at a depth of 2 km in highly saline Red Sea water. Due to its features, the sensors are a prime choice for multiple healthcare applications; for example, they are used for heart rate monitoring, plantar pressure measurements, and tactile sensing. © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim.A large-scale solar photovoltaic system (LSS PV) aims to reduce the gap as Malaysia plans to shift electricity generation from conventional sources like fossil fuels to renewable energy sources. The government plans to increase renewable energy to 20% of the generation mix by 2025. The first and second round of Malaysia's LSS programme has 958 MW of PV projects to be realized by 2020. The third round of the LSS program goes for an aggregate capacity of 500 MW. Being an intermittent source of energy, the major complication is with grid integration of the LSS PV system into the national power grid. This research aims to identify an optimum power system management scheme for LSS in Malaysia to stabilize voltage fluctuations by utilizing IEEE bus configuration. The simulation and planning of network type is based on PSS/E and PVSyst. The expected outcome of this research is to develop a solution for LSS grid integration with minimal loss in the system and in accordance with electricity standards as per Malaysian grid code.